Buscar
Mostrando ítems 271-280 de 363
Snake Venomics and Antivenomics of the Arboreal Neotropical Pitvipers Bothriechis lateralis and Bothriechis schlegelii
(2008-04-30)
We report the comparative proteomic characterization of the venoms of two related neotropical arboreal pitvipers from Costa Rica of the genus Bothriechis, B. lateralis (side-striped palm pit viper) and B. schlegelii (eyelash ...
Snake venom Lys49 myotoxins: from phospholipases A2 to non-enzymatic membrane disruptors
(2012-09)
Snake venoms often contain toxins that cause a rapid necrosis of skeletal muscle fibers,
referred to as myotoxins. The most common among them are phospholipases A2 (PLA2s),
enzymes that have two independent evolutionary ...
Trends in Snakebite Envenomation Therapy: Scientific, Technological and Public Health Considerations
(2007)
The therapy of snakebite envenomation has been based on the parenteral administration of animal-derived antivenoms. Despite the success of this treatment at reducing the impact of snakebite mortality and morbidity, mostly ...
The effect of myotoxins isolated from Bothrops snake venoms on multilamellar liposomes: relationship to phospholipase A2, anticoagulant and myotoxic activities
(1991-12)
The effect of four myotoxins isolated from Bothrops snake venoms on the release of peroxidase trapped in large multilamellar liposomes was studied and correlated to their phospholipase A2, myotoxic and anticoagulant ...
SDS‑induced hexameric oligomerization of myotoxin‑II from Bothrops asper assessed by sedimentation velocity and nuclear magnetic resonance
(2023)
We report the solution behavior, oligomerization state, and structural details of myotoxin-II purified from the venom of
Bothrops asper in the presence and absence of sodium dodecyl sulfate (SDS) and multiple lipids, as ...
Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing
(BMC Genomics, 12:259, 2011, 2011)
Background: A long term research goal of venomics, of applied importance for improving current antivenom
therapy, but also for drug discovery, is to understand the pharmacological potential of venoms. Individually ...
Group-II phospholipase A2 enzymes
(2015-05)
Phospholipase A2 are esterolytic enzymes that catalyze the hydrolysis of 1,2-diacyl-3-sn-glycerophospholipids at the C2 position, resulting in the formation of lysophospholipids and free fatty acid. They constitute one of ...
A lipidomic perspective of the action of group IIA secreted phospholipase A2 on human monocytes: lipid droplet biogenesis and activation of cytosolic phospholipase A2α
(2020)
Phospholipase A2s constitute a wide group of lipid-modifying enzymes which display a variety of functions in innate immune responses. In this work, we utilized mass spectrometry-based lipidomic approaches to investigate ...
An acidic phospholipase A2 with antibacterial activity from Porthidium nasutum snake venom
(2012-04)
Snake venoms are complex mixtures of proteins among which both basic and acidic phospholipases A2
(PLA2s) can be found. Basic PLA2s are usually responsible for major toxic effects induced by snake venoms,
while acidic ...
Proteomic analysis of the mandibular glands from the Chinese crocodile lizard, Shinisaurus crocodilurus – another venomous lizard?
(2023)
Based on its phylogenetic relationship to monitor lizards (Varanidae), Gila monsters (Heloderma spp.), and the earless monitor Lanthanotus borneesis, the Chinese crocodile lizard, Shinisaurus crocodilurus, has been assigned ...