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Phosphatidylinositol 3-Kinase/Akt Pathway Targets Acetylation of Smad3 through Smad3/CREB-binding Protein Interaction: Contribution to transforming growth factor 1-induced epstein-barr virus reactivation
dc.creator | Oussaief, Lassad | |
dc.creator | Hippocrate, Aurélie | |
dc.creator | Ramírez Mayorga, Vanessa | |
dc.creator | Rampanou, Aurore | |
dc.creator | Zhang, Wei | |
dc.creator | Meyers, David | |
dc.creator | Cole, Philip | |
dc.creator | Khelifa, Ridha | |
dc.creator | Joab, Irène | |
dc.date.accessioned | 2015-05-26T21:34:16Z | |
dc.date.available | 2015-05-26T21:34:16Z | |
dc.date.issued | 2009-09-04 | |
dc.identifier.citation | http://www.jbc.org/content/284/36/23912.full | |
dc.identifier.issn | 0021-9258 | |
dc.identifier.uri | https://hdl.handle.net/10669/13346 | |
dc.description | Artículo científico -- Universidad de Costa Rica, Instituto de Investigaciones en Salud. 2009. Este documento es privado debido a limitaciones de derechos de autor. | es_ES |
dc.description.abstract | Epstein-Barr virus, a ubiquitous human herpesvirus, is associated with the development of carcinomas and lymphomas. We previously showed that transforming growth factor 1 (TGF- 1) mediated the virus to enter the lytic cycle, which is triggered by expression of Z Epstein-Barr virus replication activator (ZEBRA), through the ERK 1/2 MAPK signaling pathway. We report here that Akt, activated downstream from ERK 1/2, was required for TGF- 1-induced ZEBRA expression and enabled Smad3, a mediator of TGF- 1 signaling, to be acetylated by direct interaction with the co-activator CREB-binding protein and then to regulate TGF- 1-induced ZEBRA expression. | es_ES |
dc.description.sponsorship | Universidad de Costa Rica, Instituto de Investigaciones en Salud. | es_ES |
dc.description.sponsorship | John Hopkins University, Department of Pharmacology and Molecular Sciences | es_ES |
dc.language.iso | en_US | es_ES |
dc.publisher | THE JOURNAL OF BIOLOGICAL CHEMISTRY 284(36), pp. 23912–23924 | es_ES |
dc.source | The Journal of Biological Chemistry, 2009, 284(36): 23912-23924 | es_ES |
dc.subject | lymphomas | es_ES |
dc.subject | Salud pública | es_ES |
dc.title | Phosphatidylinositol 3-Kinase/Akt Pathway Targets Acetylation of Smad3 through Smad3/CREB-binding Protein Interaction: Contribution to transforming growth factor 1-induced epstein-barr virus reactivation | es_ES |
dc.type | artículo original | |
dc.identifier.doi | 10.1074/jbc.M109.036483 | |
dc.description.procedence | UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA) | es_ES |
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Microbiología [1171]