Individual differences in the forced swimming test and neurochemical kinetics in the rat brain
artículo original
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2014-02-08Autor
Sequeira Cordero, Andrey
Mora Gallegos, Andrea
Cuenca Berger, Patricia
Fornaguera Trías, Jaime
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Individual differences in the forced swimming test (FST) could be associatedwith differential temporal dynamics
of gene expression and neurotransmitter activity. We tested juvenile male rats in the FST and classified the
animals into those with low and high immobility according to the amount of immobility time recorded in FST.
These groups and a control group which did not undergo the FST were sacrificed either 1, 6 or 24 h after the
test. We analyzed the expression of the CRF, CRFR1, BDNF and TrkB in the prefrontal cortex, hippocampus and
nucleus accumbens as well as norepinephrine, dopamine, serotonin, glutamate, GABA and glutamine in the
hippocampus and nucleus accumbens. Animals with low immobility showed significant reductions of BDNF
expression across time points in both the prefrontal cortex and the nucleus accumbens when compared with
non-swim control. Moreover, rats with high immobility only showed a significant decrease of BDNF expression
in the prefrontal cortex 6 h after the FST. Regarding neurotransmitters, only accumbal dopamine turnover
and hippocampal glutamate content showed an effect of individual differences (i.e. animals with low and high
immobility), whereas nearly all parameters showed significant differences across time points. Correlational
analyses suggest that immobility in the FST, probably reflecting despair, is related to prefrontal cortical BDNF
and to the kinetics observed in several other neurochemical parameters. Taken together, our results suggest
that individual differences observed in depression-like behavior can be associated not only with changes in the
concentrations of key neurochemical factors but also with differential time courses of such factors.
External link to the item
10.1016/j.physbeh.2014.01.037
artículo -- Universidad de Costa Rica, Instituto de Investigaciones en Salud y Centro de Investigación en Neurociencias. 2014. Este documento es privado debido a limitaciones de derechos de autor.
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