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dc.creatorEscamilla, Michael
dc.creatorHare, Elizabeth
dc.creatorDassori, Albana
dc.creatorPeralta, Juan Manuel
dc.creatorOntiveros, Humberto
dc.creatorNicolini Sánchez, José Humberto
dc.creatorMedina, Rolando
dc.creatorMendoza Rodríguez, Ricardo
dc.creatorMuñoz, Rodrigo
dc.creatorAlmasy, Laura
dc.creatorRaventós Vorst, Henriette
dc.creatorJerez, Álvaro
dc.date.accessioned2014-05-26T17:05:20Z
dc.date.available2014-05-26T17:05:20Z
dc.date.issued2009-02-02
dc.identifier.citationhttp://ajp.psychiatryonline.org/article.aspx?articleID=100726&resultClick=1es
dc.identifier.issn0002-953X
dc.identifier.otherESSN: 1535-7228
dc.identifier.urihttp://hdl.handle.net/10669/11068
dc.descriptionartículo (arbitrado) -- Universidad de Costa Rica. Centro de Investigación en Biología Celular y Molecular, 2009. Este documento es privado debido a limitaciones de derechos de autores
dc.description.abstractThe present study investigated a new set of families of Latin American ancestry in order to detect the location of genes predisposing to schizophrenia and related psychotic disorders. Method: A genome-wide scan was performed for 175 newly recruited families with at least two siblings suffering from a psychotic disorder. Best-estimate consensus procedures were used to arrive at diagnoses, and nonparametric allele-sharing statistics were calculated to detect linkage. Results: Genome-wide significant evidence for linkage for the phenotype of DSM-IV schizophrenia or schizoaffective disorder was found in a region on chromosome 17q21 (lod score, 3.33). A region on chromosome 15q22-23 showed suggestive evidence of linkage with this same phenotype (lod score, 2.11). Analyses using a broader model (any psychosis) yielded evidence of suggestive linkage for the 17q21 region only, and no region achieved genome- wide significance of linkage.es
dc.description.sponsorshipUniversidad de Costa Ricaes
dc.language.isoen_USes
dc.publisherAm J Psychiatry 2009;166:442-449es
dc.relationAm J Psychiatry 2009;166:442-449es
dc.subjectAmérica Latinaes
dc.subjectGenéticaes
dc.subjectEsquizofreniaes
dc.subjectEnfermedad mentales
dc.subjectPsicosises
dc.subjectSchizophrenia
dc.subjectGenetics
dc.subjectSalud mental
dc.titleA schizophrenia gene locus on chromosome 17q21 in a new set of families of mexican and central american ancestry: evidence from the NIMH genetics of schizophrenia in latino populations studyes
dc.typeinfo:eu-repo/semantics/articlees
dc.typeArtículo científicoes_ES
dc.identifier.doi10.1176/appi.ajp.2008.08040612
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM)es


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