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dc.creatorHare, Elizabeth
dc.creatorGlahn, David C.
dc.creatorDassori, Albana
dc.creatorRaventós Vorst, Henriette
dc.creatorNicolini Sánchez, José Humberto
dc.creatorOntiveros Sánchez de la Barquera, Jose Alfonso
dc.creatorMedina, Rolando
dc.creatorMendoza Rodríguez, Ricardo
dc.creatorJerez, Álvaro
dc.creatorMuñoz, Rodrigo
dc.creatorAlmasy, Laura
dc.creatorEscamilla, Michael
dc.date.accessioned2014-05-26T16:33:39Z
dc.date.available2014-05-26T16:33:39Z
dc.date.issued2009-04
dc.identifier.issn1552-4841
dc.identifier.otheressn:1552-485X
dc.identifier.urihttp://hdl.handle.net/10669/11067
dc.descriptionreporte técnico (arbitrado) -- Universidad de Costa Rica. Centro de Investigación en Biología Celular y Molecular, 2009. Este documento es privado debido a limitaciones de derechos de autores
dc.description.abstractSchizophrenia is a genetically complex illness with heterogeneous clinical presentation, including variable age ofonset. In this study, the heritability, or proportion of variation in age of onset of psychotic symptoms due to genetic factors, was estimated using a maximum likelihood method. The subjects were 717 members of families with more than one member affected with schizophrenia from Mexican and CentralAmerican populations. Age of onset of psychosis was determined by best-estimate consensus diagnosis based on the Diagnostic Interview for Genetic Studies, Family Interview for Genetic Studies, and each subject’s medical records. Mean age of onset was 21.44 years (SD 8.07); 20.55 years for males (SD 6.90), and 22.67 for females (SD 9.34). Variance components were estimated using a polygenic model in the SOLAR software package. The sex of the participant was a significant covariate (P¼0.010) accountingfor 0.02 of the total variance in age ofonset. The heritability of age of onset of psychosis was 0.33 (SE¼0.09; P¼0.00004). These findings suggest that genetic factors significantly contribute to the age of onset of psychotic symptoms in individuals with schizophrenia and that sex influences this trait as well.es
dc.description.sponsorshipUniversidad de Costa Ricaes
dc.language.isoen_USes
dc.publisherAMERICAN JOURNAL OF MEDICAL GENETICS PART Bes
dc.subjectEsquizofreniaes
dc.subjectPsicosises
dc.subjectGenéticaes
dc.subjectSalud mentales
dc.subjectEnfermedades
dc.titleHeritability of Age of Onset of Psychosis in Schizophreniaes
dc.typeinfo:eu-repo/semantics/reportes_ES
dc.typeReporte técnicoes_ES
dc.identifier.doi10.1002/ajmg.b.30959
dc.description.procedenceUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM)es


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