Listar por autor "James, Helen E."
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Disease-associated CAG·CTG triplet repeats expand rapidly in non-dividing mouse cells, but cell cycle arrest is insufficient to drive expansion
Gomes Prereira, Mario; James D., Hilley; Morales Montero, Fernando; Berit, Adam; James, Helen E.; Monckton, Darren G. (Nucleic Acids Research 42(11) p. 7047–7056, 2014-05-01)Genetically unstable expanded CAG·CTG trinucleotide repeats are causal in a number of human disorders, including Huntington disease and myotonic dystrophy type 1. It is still widely assumed that DNA polymerase slippage ...